PartoSure

Features

PartoSure™

The PartoSure Test is a rapid, non-invasive strip test for the detection of placental alpha microglobulin-1 (PAMG-1) in patients presenting with signs and symptoms of preterm labour.

  • PartoSure’s unique features include:
  • High Positive (PPV) and Negative Predictive Value (NPV)
  • Usable shortly after vaginal exam
  • Speculum examination optional
  • Results in 5 minutes or less
  • No special equipment or training needed
  • Wide gestational age range from 20 to 37 weeks

Overview

The European Association of Perinatal Medicine published its updated Preterm Labor and Birth Management Guidelines in 2017, and the PartoSure test’s placental alpha-microglobulin-1 (PAMG-1) was identified as the biomarker test with the highest combination of negative predictive value (NPV) and positive predictive value (PPV) to be used in women with equivocal cervical length measurements between 15 and 30 mm.

A recent large scale meta-analysis comparing PartoSure with all other biomarkers confirms that the PAMG-1 test was found to have the highest PPV and LR+ across all risk stratification groups with statistical significance.

As few as 3% of pregnant women experiencing signs and symptoms of preterm labour actually progress to delivering within the seven ensuing days. Discharging patients home creates the risk of a potentially avoidable adverse outcome, yet prophylactically admitting them for observation incurs considerable costs to the healthcare system and disruptions to the mother and family’s life. 

Given the potential of a positive biomarker test to influence the decision to admit and/or treat, the PartoSure test leads to reductions in unnecessary hospitalizations and in-utero transfers to tertiary care centres and allows for more judicious use of therapeutic interventions, such as antenatal corticosteroids and tocolytic agents.